If you play Life backwards, it's about people ungrowing then got shoved into their mum's stomach.

If you play Doom 3 backwards, it's about a guy called Flynn Taggart that creates a demon called The Cyberdemon in hell, then gets on Mars through a portal, creates shitloads of zombies and demons and leaves Mars on a spaceship.

If you play Half-Life backwards, it's about a guy who escapes from a parallel dimension and manages to seal it off with a resonance cascade.

I would totally play this. It's a game about the heroine allowing a goddess to rule the land, then she goes home spawning hundreds of fairies and healing random people. The game starts with the protagonist and the goddess puking tea.

Street Fighter - It's about a group of people inexplicably destroying the world by healing each other.

Bastion - Some guy causes the world to break down and fall apart as he runs along it.

PAYDAY: The Heist - A group of guys go around giving money to banks and other wealthy organizations.

If you play Dota 2 backwards you find yourself building towers and bring people with swordhits alive.

If you play TrackMania backwards, it's about cars that drive from their world records and finishes to back where they started, reliving all checkpoints.

EYE Divine Cybermancy - Nobody would notice. It would equally make absolutely no sense whatsoever.

If you play Surgery Simulator backwards...

Well... Just don't.

What would happen if you played the new Syndicate backwards? Nobody knows, since nobody played it.

Rape Lay backwards - Doesn't get any less creepy and wrong...

If you play COD backwards,it still sucks.

inb4 fanboys

If you watch the Spiderman trilogy backwards you will still lose brain cells.

If you play Grand Theft Auto IV backwards, it's about a war-troubled Serbian who revives people and solves crimes, donates money to banks, leeches money of his cousin, leaves America and makes a war undone.

If you play Terraria/Minecraft backwards, it's about a person reviving countless entities while bringing down constructions, re-establishing natural resources and restoring landscapes to their former glory

If you play the sims backwards its about a sim which you raised from the death on purpose until hes is too young and goes back in the green thingy-lingy of the mother sim where he will never get out of again... Oh yeah it ends with sex!

If you play Assassins Creed 2 backwards, its about a guy starting the game by swearing, revives the Pope, gets out of Rome, jumps backwards on buildings, revives over 100 guards, goes back in his mother, and Desmond leaves the Animus 2.0 and goes back to Abstergo.
And then: Assassins Creed.

If you play Eversion backwards, it's still a cutesy little platformer. ^_^

braid :P

If you play GRID backwards it's about people reversing cars at speed.

And, heh, I can't believe I missed this easy one. If you play Inside a Star-filled Sky backwards, it's exactly the same only you absorb bullets.

If you play Rock of Ages backwards it's about large rocks who revive famous figures from history before rolling uphill.

If you play Railworks backwards it's about the world's worst-run rail transport franchise.

Mario runs away from a castle in every world until he finds out the princess needs saved, but he gets a beer instead, and the princess is never found.

Pretty sure you know the game.

If you play Faerie Solitaire backwards it's about someone dealing cards.