Recomendation of Sci-fi movies or series little known

Example of thinks I already watch and are in the thematic (To make an idea):
-Anime: Planetes
-Anime: Psycho-Pass
-Series: Firefly
-Movie: Æon Flux
-Movie: La jetée
-Movie: The Thirteenth Floor
-Movie: Equilibrium

Example of thinks I have not seen yet but looks in the line (To make an idea of the areas where I am profane):
-Series: Total Recall: 2070
-Anime: No.6
-Anime: Gargantia on the Verdurous Planet

Example of thinks not in the line:
-Series: Eureka!
-Series: Warehouse 13

Example of thinks I consider "Little known":
-Anime: Planetes
-Movie: Primer
-Movie: La jetée
-Movie: The Thirteenth Floor
-Movie: Equilibrium

Hard to tell what is "little known" for you. ^^
Since I don't know what you really looking for... maybe these?
Anime: No.6
Movie: Æon Flux

Check The Cyberpunk Movies Database and The Biopunk Movies Database

If I have to single out a movie it will be La jetée by Chris Marker. It's more of a photonovel than a movie but still great

Planetes is a pretty good obscure one. It's basically the story of a group of space trash collectors who work to make sure that no space debris collides with their company's property.

While its heavily mainstream and well known the Deus Ex games have a great dystopic cyberpunk look

have you heard of Gargantia on the Verdurous Planet?

Hmm, not sure if it works, but maybe Psycho-Pass?

Firefly!

Eureka!

https://en.wikipedia.org/wiki/Eureka_(U.S._TV_series)

Try Total Recall: 2070 (series)

The Fall (movie)...although...no thats fantasy...
Equilibrium?

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some horror game...please leave a reply if u take it

ghost in the shell

prolly already mentioned...cyber punk anime...great movie

warhammer 40k is pretty dark...there was a cgi movie
http://www.imdb.com/title/tt1679332/?ref_=nv_sr_1

TV Series : Babylon 5 (ok its fairly well known, but its not current and its absolutely amazing (once you get past the first season)
Movie : Immortal (its a French movie, also known as Ad Vitam or Nikopol), not super well known but there is also a game and it is definitely interesting

I've got plenty of other suggestions but I could go on forever and I think the two above fit your bill.

Not sure about your "little known" part:
Idiocracy
Soylent Green
Metropolis
not sure if there is an english version: Welt am Draht

In case books are fine too:
Asimov's robot + foundation series
Orwell's 1984
Kafka's The Trail
Dick's Minority Report among others
Burgess' A Clockwork Orange (also the movie)
Gibson's Neuromancer
Doctorow's Little Brother

There was a television series called 'Earth 2'. Very interesting. Got cancelled with a very bad cliffhanger. As for films, plenty. Not very sci-fi, but post-apocalyptic would be 'The Book of Eli'. Quite interesting. Also post-apocalyptic and more sci-fi is 'Snowpiercer'. I don't think 'Dark City' would be considered not very known. Then 'Pandorum' is more clearly sci-fi as well.

Obviously things like 'SOMA' in terms of games are a must, if games are included in your research. 'Cradle' might also be similar in some aspects and also features transhumanism, though I have not played or seen much of it.

What comes to mind is:
Lexx TV series
Almost Human TV series
12 monkeys movie and TV
Children of Men movie
The Road movie
Blame! manga and short anime
Texhnolyze anime
Ergo Proxy anime