Games with great replayability

Civilization

For me it's ME Trilogy, DA:0, evey-single-fuckin-game of The Elder Scrolls series (well, Redguard was not so good) and The Witcher series. And Fallouts.

Dark Souls

Pretty much all oldschool RPG's, Baldurs Gate, Icewind Dale, Neverwinter nights, Planescape Torment, Gothic 1 & 2.

Serious Sam, Painkiller and similar dumb-but-fun shooters.

Devil May Cry series

Turn-based strategy games, like Civ5 and Heroes III.

Beyond Good and Evil and The Witcher of course :D

Civilization V ofc, and everybody have it anyway, after that goldenjoysticks madness last month :)

CS GO, Civ 5, Arma 3

Anything with randomly generated levels is a good bet.

Games like Dungeons of Dredmor, The Binding of Isaac and Spelunky come to mind.

I'd recommend sandboxes games like Terraria, Minecraft and Dont Starve. Terraria its the best replay game ever imo!
I don't know if this suit to the thread but I also recommend League of Legends and Dota 2.

FTL

I keep going back to Minecraft and Terraria. Lately I've been playing Terraria every chance I get.

I also logged a ton of hours into War of the Roses. It's all multiplayer and I haven't logged on in a while so I don't know if it's still being played, but it was really fun.

I only want to add Stalker series and Dishonored to the list.

Three that come to mind are FTL - Faster Than Light, Minecraft, and Spelunky.

You can even get the original version of Spelunky for free.

Audiosurf, Beat Hazard Ultra, Garry's Mod, TF2, Portal 2, Left 4 Dead 2, Cities XL... and Red Faction Guerrilla if you like to re-play the campaign just to blow up more buildings :))

Sandboxes and some multiplayer games have high replayability, because if they didn't, they wouldn't survive.

Call of Duty : Ghosts, so many choices and endings that influence the universe around you.
One time you may reload an entire magazine, other times you may fire 1 shot and reload and so on; each of these decisions ultimately decide your fate.

• The Binding of Isaac
• Super Hexagon
• FTL: Faster Than Light
• Papers, Please
• Game Dev Tycoon

I'll add more as I think of them

Deus Ex(1), System Shock 2, TES3-Morrowind, Age of Empires(1), Quake(1), Diablo(1)/Hellfire, zuma, chess..... ;)

Off the top of mu head:

• The HoMM series (except IV and VI)
• The whole Civ series (except III maybe), with Alpha Centauri and the original Colonization receiving a speacial seat at the table
• Many roguelikes, especially SOTS: The Pit, FTL, The Binding of Isaac
• Europa Universalis and Crusader Kings series (Victoria and Hearts of Iron series are not everybody's cup of tea)
• Minecraft, obviously
• Railroad Tycoon II + III

You wanted only PC titles, but these I had to mention:

• Many C64 titles, especially worth remembering: Pirates!, Seven Cities of Gold, Elite, Defender of the Crown

sids civilisation V

Dungeon of Dredmor, Vampire the Masquerade: Bloodlines immediately come to mind but most RPGs work well in this category.

FTL,payday series,civ series,GTA series

FTL,payday series,civ series,GTA series

FTL, and any 4X game really(My personal favorite of the 4X genre being Sins of a Solar Empire, or Civ V). Open ended RPGs like the Elder Scrolls series, or Neverwinter Nights/Baulder's Gate/Planescape: Torment are also good for replayability if you're not into 4Xes. After that you're looking at sandbox games like Terraria, Space Engineers, Minecraft, Gray's Mod, etc. FPS games always come dead last in the replay stats, unless you like playing multiplayer with 12 year olds.

Chess ^^ ;-)