Hottest video game chick?

Aya Brea I'd say, from Parasite Eve.

I'm gonna go with Karliah from Skyrim.

Yeah, she's got a Bethesda face, but use your imagination a little. Dunmer (Dark Elves) are pretty exotic that would start, in the real world, with an Asian look, but go far beyond. Plus... dem purple eyes, and dat voice...

Link goes to a 1080p screenshot, so if you want a wallpaper...

I have a thing for redheads, so I am probably a bit biased, but I love the way Nariko from Heavenly Sword looks

Anivia from League of Legends.

Stella Nox Fleuret
bonus
unfortunately FFXV still not release yet :P

Moira :D

All of them from The Witcher series.

SHODAN!!!!!!!!!!

Any random female LoL champion

Catwomen from Batman: Arkham City.

Faith from the new Mirrors Edge trailer.

The female Marine from Natural Selection 2

because actual armor.

Probably not the most popular opinion, but Fiora Laurent <3

Shurelia from Ar Tonelico Melody of Elemia

I just can't decide between Lara Croft from Tomb Raider (2013), Ayame from Tenchu series, or Tifa with from Advent Children (she does appear in games with that outfit such as Dirge of Cerberus and Kingdom Hearts II)

EDIT: Forgot this one, but I kinda fall in love to Alice in Wonderland story because of Alice Lidell in Alice: Madness Return. She's somewhat lovely.

Christie Montiero from Tekken? Or Lara Croft from Tomb Raider...hmm

Ms. Pacman XD