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Alright, you did include gaming, so here's my favorite channel Gopher
He's a brit living in Norway, mostly plays Bethesda games, awesome at immersing into the game and role-playing, is a modder and has a great sense of humor.
Also worth noting:
Worthabuy - funny British guy with hilarious rants on gaming.
ItsAGundam - mostly does commentary on stupid things that happen in gaming, twitch and stuff, awesome guy.
LiliaTV - in my opinion the best female gaming channel on youtube and twitch. Really sweet and nice, which creates a cosy atmosphere on all her streams. Only plays single-player games.😍

Jacksepticeye
comedy+gaming+swearing+bit of voice acting for game characters

https://www.youtube.com/user/TheRelaxingEnd - Unboxing

Internet Today - https://www.youtube.com/channel/UCyZVCV9xhrCyz4hPehvb4Wg

SsethTzeentach, one of the best gaming reviews out there.
https://www.youtube.com/user/SsethTzeentach

i thought this was something i would not be interested in... but since November i been captured by Japanese gaming vtubers, im not that into anime, and neither of the cutesy side of it... but they are fun and chill.
Almost all of them stream in Japanese but theres a big community of translators, here are some clips:
Minecraft moments
3D fun
Matsuri's world famous story
This group....
IRL meeting goes wrong
spooky screaming

Matty Matheson. i'm just dropping this name here.

Funhaus.

That is all.

CJUGames - He's my favorite gaming channel right now because he's not obnoxiously loud nor is he overly dramatic or fakes his reactions.
ChosenArchitect - Chill dude. Does mainly Minecraft stuff.
ACG - Usually where I check for reviews when I'm interested in games.
CinemaSins - He does "Everything wrong with (enter movie title here)" videos and personally, I find them quite funny.
Alter - In case you want to watch some short horror films.
Dust - In case you want to watch some Scifi short films.
Chris Ramsay - Dude who does puzzles and magic.

Dunno whether it's been mentioned already, but this is my favorite comedy channel:
Ozzy Man Reviews

https://www.youtube.com/channel/UC3Kk8tvhHkWMMfKBb0q0X9g - aquarium
https://www.youtube.com/user/AntsCanada/ - ants
https://www.youtube.com/channel/UC7MCFUG5oKKsfVDl7gT7BRA - fish

Ahoy - Gaming Historian
https://www.youtube.com/user/XboxAhoy/videos

Modern Vintage Gamer: https://www.youtube.com/channel/UCjFaPUcJU1vwk193mnW_w1w

CohhCarnage for gaming

MeatCanyon make messed up animated shorts

I used to watch Noel Fielding's Luxury Comedy with my ex.
I watch JennaMarbles with my current girlfriend.
CallMeKevin is a funny gamer.

Some great comedy from Key and Peele

https://www.youtube.com/channel/UCdN4aXTrHAtfgbVG9HjBmxQ

Being the elite - young bucks vlog.
https://www.youtube.com/channel/UC2V6TA0OqHr9BojcHz9az-w
Carlsagan42 - plays a lot of troll levels
https://www.youtube.com/user/CarlSagan42
Dead Parrot - various British conedy shows
https://www.youtube.com/user/DeadParrotA3M
Franchise Kicks - uboxing and wrestling
https://www.youtube.com/user/chicagocubs1980
Larry bundy Jr - obscure gaming facts
https://www.youtube.com/user/LarryBundyJr
Movie Schmoedown - host their own movie trivia show with competing teams.
https://www.youtube.com/user/schmoesknow
Cultaholic - wrestling news, reactions and wtf moments
https://www.youtube.com/channel/UCjcPJbFDwVZZELGG38q2cLQ

Some of my favs, mostly lesser known:

https://www.youtube.com/channel/UC9ff15w4ufviWfv9UfIuByA
https://www.youtube.com/channel/UCJxAk5DKwJFwaFGT1BY2V5w
https://www.youtube.com/channel/UCkDSAQ_5-yx5hmuvUcsJL7A
https://www.youtube.com/user/tthompso/featured
https://www.youtube.com/channel/UCqY4_uXyOSwpbPpO4qiNDVA (German)

https://www.youtube.com/channel/UCPJJQWqWczfPjidTSX4Lu5w?view_as=subscriber
https://www.youtube.com/channel/UC9DWJ33CMvIseLlyx6hyRnA
https://www.youtube.com/channel/UCR4s1DE9J4DHzZYXMltSMAg

How about these 3 channels?

Just 1 single key critical word: Tyrannicon.

You'll love it.

Accursed Farms is probably my favorite; I love his sense of humor and just some of the weird games he comes up with; it's very rare that I've heard of them.
Clockwork Pixel is worth a look, if you want something creepy; it's pixel art animation with a Horror theme.
Ever wonder how to know which rom hacks are any good? Well, if you're into Mario (mostly Super Mario World), then Self-Made Island has you covered!
Todd in the Shadows is one of my favorite music critics; even though I don't always agree with him, he's always good for a laugh.
Lady Pelvic is similar, but she reviews video games; even if I'm not that interested in the game, I usually watch, because I love her personality. And that hair! ❤

Look up Redacted Tonight, and Survival Russia. Both fun channels, for very different reasons.