Final Fantasy 3 and 4, Neverwinter Nights, Diablo 2, Pokemon.
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These are my picks (though this is somewhat of an abridged list):
I have Shin Megami Tensei: Persona 4 but I haven't played it yet so I can't comment.
Also, here are my (again, abridged) picks for worst role-playing games (which are also examples of how multi-platformism kills PC gaming series):
I would also add Thief: Deadly Shadows to the list but it isn't a role-playing game. It is, however, another example (like the others listed) of how multi-platformism (whether by a different company or the one that created the original) always results in the destruction of established and beloved PC game series.
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RPG = Deus Ex series, Fallout 3 and New Vegas, Kingdoms of Alamur, Morrowind, Vampire: The Masquerade - Bloodlines, Anachronox, Star Wars: Knights of the Old Republic, Dragon Age 1 and Mass Effect series
ARPG = Titan Quest & Titan Quest: Immortal Throne (Kicks Diablo 3 back to the stone age and TQ is six years older.).
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Pokémon Yellow, Pokémon FireRed , Final Fantasy VII, Fire Emblem (Blazing Sword, The Sacred Stones and Fuuin no Tsurugi) and Kingdom Hearts 2.
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Inb4 Skryim,
But seriously, throwing my few into the pot I'm voting,
Persona 4
Kingdom Hearts
Chrono Trigger
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