What are your favorite games that can be played one handed?

darkest dungeon.
https://store.steampowered.com/app/262060/

Plague Inc: Evolved
https://store.steampowered.com/app/246620/

TWD telltale is great! Pretty sure Crypt of the Necrodancer (https://store.steampowered.com/app/247080/) can be played just using the arrow keys. Great game with great music. If I can think of any others I'll let you know :)

Never thought about games that you can play with 1 hand, so let's see...
Heroes of might and magic (or any turn-based strategy for that matter).
Tower defense games (in my case it's Defense Grid series).
Random games like The room, Tharsis, FTL, Papers, Please.
A lot of visual novels (which you probably dislike more than point'n'clicks :D) and... point'n'click games.
Personally, i think you have all that you need with fallouts and telltale games.

I guess any turn-based rpg game (Final fantasy, The legend of heroes, Dragon Quest, etc.)
And if you want something less weeb...Cities Skylines.

Off the top of my head, I know that Advance Wars is a solid turn-based tactics game, and since it's turn-based, you can play it with one hand.

https://store.steampowered.com/app/237430/Expeditions_Conquistador/
and
https://store.steampowered.com/app/208520/Omerta__City_of_Gangsters/

Both can be played just using the mouse.
The bad thing, sometimes both are a bit frustrating...

How to Use the On-Screen Keyboard on Windows 7, 8, and 10
For your convenience, you can make keyboard input with your mouse.

FTL: Faster Than Light
In this game, you can select with the mouse.
You can "pause" by pressing the space key during battle.
Various instructions can be given during "pause".
You can probably play.

dude.
pocket pinball.
its just as much fun with only 1 flipper.
lol.
i went through my game list looking for other GOOD 1 handed games but i couldnt find any
if you end up playing a P&C game. dropsy and i have no mouth and i must scream.
but i dont dig P&C games ether.

Sorry about your hand.
Strategy Games, RPGs, and Puzzles are obvious avenues to check. Some suggestions:
Age of Wonders III
Creeper World series
Legend of Grimrock
Divinity: Original Sin
Mini Metro
Some Puzzles

Sorry about your hand, buddy. Obviously most regular games will be off limits for awhile so you've gotta think outside the box.

The Stillness of the Wind
https://store.steampowered.com/app/828900/

The Darkside Detective (this one is a point n click game which you said you dont like but I found the humor to be really enjoyable and made the game worth playing)
https://store.steampowered.com/app/368390/

Do Not Feed the Monkeys (kind of like Orwell mixed with humor)
https://store.steampowered.com/app/658850/

The Gods Will Be Watching (surprisingly hard sci-fi game)
https://store.steampowered.com/app/274290/

I hope you get some good suggestions from this thread. Take care of yourself and heal up soon. Best wishes.

The infinity engine games. just bind the pause button to your right mouse button or something and you're good.

I'm sure many RPGMaker games can be played one handed, I would highly recommend To The Moon and Finding Paradise. Mad Father and The Witch's House are also quite good. Ib is another fantastic game, though not on steam

That's terrible what happened to your hand :(

I don't like the point and click genre too. How about Slay the Spire or Steamworld Quest: Hand of Gilgamech if you like card games that is! Any turn-based games would be okay too, I believe

https://store.steampowered.com/app/740240/ Very addicting
https://store.steampowered.com/app/338120/
https://store.steampowered.com/app/255710/ Should be somewhat playable even with only one hand
https://store.steampowered.com/bundle/6588/Monkey_Island_Collection/ Point and Click though. Curse was my favorite of the four, even though i never got to finish it.
https://store.steampowered.com/app/418240/Shadow_Tactics_Blades_of_the_Shogun/ Definitely playable with one hand, as ive done it myself out of lazyness. But sometimes having another hand would make somethings a little bit easier for the shortcut commands. I would also recommend all of the Commandos games which are of the same style of gameplay, but im not sure if only one hand is enough. Nonetheless Blades of the shogun has a demo on that very steam page you can try out before getting it.

Edit:
Oh i forgot about
https://store.steampowered.com/app/38600/Faerie_Solitaire/ There is a remastered version too.
https://store.steampowered.com/app/700660/Dice_Tower_Defense/ Small game for small fun :)
Given this i could suggest also Tower Defense games: https://store.steampowered.com/tags/en/Tower%20Defense/#p=0&tab=TopSellers
Like:
https://store.steampowered.com/app/18500/Defense_Grid_The_Awakening/
or
https://store.steampowered.com/app/296490/GemCraft__Chasing_Shadows/

I'm not sure if they require a 2nd hand though.

Edit2:
There is also card games like Artifact which can be fun.
Backgammon/chess/minesweeper(non steam)
I also remember playing a Risk type game which was fun too(non steam)
Maybe also Uno / Monopoly / Tabletop Games(not sure how tabletop simulator works regarding playing one handed)
Also some strategy war games are viable to play with one hand. Age of empires came to mind, wont delve in too much into this this wide category,

Into the Breach! I think I've only ever used my mouse (so just one hand) while playing this. Needed to press a key or two sometimes during gameplay, but 98% of the time - a keyboard is never needed (from my experience at least). You can take your time with ItB. Don't know if you enjoy turn-based titles and while this one kicks my butt, I do suggest it.

Other nice things about it:

• you can hop on the game, play in bursts of like 5-10 minutes
• challenges you and makes you think of your moves
• it's intense enough, but yet still chill enough (if that makes sense) to the point you can listen to other music, etc. while playing
• combination of pixel art + isometric viewpoint is cool imho
• you have a squad & captains
• mechs, weird creatures and more...

The Telltale games are good options too (Tales of Borderlands will mostly likely cheer you up in some way), though many parts will require you to use m+kb, like when you explore a room & walk/talk to NPCs and interact with objects. Also while usually most of its Quick time events (QTE) just asks you to press a key, some segments require you to multitask & use m+kb during it (if I remember correctly D: )

Also, holy crap, that is scary and horrible dude. 😨I don't think I have the right words to say, but just gonna send some good vibes to you ~

This War of Mine
Papers, please
Undertale
If I can recall correctly, Cat Quest has a mouse'-solo option

Equilinox
Islanders
Premium Bowling

I hope you'll get better soon.
FTL
https://store.steampowered.com/app/212680/FTL_Faster_Than_Light/
Jets'n'Guns Gold
https://store.steampowered.com/app/262260/JetsnGuns_Gold/

Mouse only:

https://magic.wizards.com/en/mtgarena

Lol, that would be one of my favourite games, Earthbound.

Rhythm Heaven Fever is another good example as the Wiimote suits its one handed play very well.

View attached image.