What are the best games to only play with a mouse? Like point and click

Majesty: The Fantasy Kingdom Sim can easily be played with just a mouse.

Elven Legacy, Fantasy Wars, Galactic Assault, Civilization 2-5, Theme Hospital, Myst 1-5, Syberia 1-2, Monkey Island 1-3, Still Life, Resonance, Reversion, Sam & Max, Scratches, The Last Express, Diablo, The Longest Journey, Fallout 1-2, Final Liberation, Emperor of the Fading Suns, Stars! & I could go on for a long time here.

torchlight you will play with mouse only for the 80% of the game.

Sam and max series :3

Gray Matter

MS Paint.

Heroes of Might&Magic II-VI
Disciples I-II (NOT III)
Eador.

Riven / Myst III: Exile

Seriously the Myst series is great, if you like engrossing/surreal game worlds and also a bit of clever problem/puzzle-solving. The games are not "hard", but just kinda require approaching things with an open mind and being a bit thoughtful about how to figure out the right way to solve a "puzzle" (altho puzzle is rarely the right word for the obstacles/mechanics in the games).

If you haven't played them, classic LucasArts adventure games like: Loom / Indiana Jones and the Fate of Atlantis / Monkey Island series / Day of the Tentacle

You could also play RTS games like: WarCraft 3 (wicked storyline) / StarCraft 1 and/or 2

-Diablo series :)

-The Sims series

-Torchlight 2, super fun game!

Broken Sword and Monkey Island series

beneath a steel sky

Superbrothers!

Torchlight 2!

Symphony! Shooting space ships while listening to your favourite music. How awesome is that?

Seriously, very nice game. I think the best of those adapting to music.

FTL: Faster Than Light, if you have the skills, you don't even need the space bar

Try droplitz. I just lay back and play before going to sleep.