Most meaningful video games?

We all play a lot of video games that have been praised for their gameplay, creative story, graphics, etc.

I'm looking for good video games that are also meaningful. The Last of Us is an example - it deals with deep themes like sacrifice, fate, loyalty, human nature, and the human situation. Deus Ex is also viable - it makes us question the morality of human modification, and how far we can go before we cross a line.

Minecraft isn't a very good example - in it, you run around, chop trees, build houses, and kill monsters. Creative and fun, but not meaningful and moral. Actually, see the quote below

What are some suggestions?

EDIT:
A quote: "The question is flawed, it's a lot like asking what the most meaningful book is a lot of different books are meaningful in different ways. Your example of minecraft being not meaningful already shows the limitation of what you consider meaning. Minecraft is very meaningful as an outlet of self expression and self exploration." -abyssion1337

Thoughtful and insightful. Interesting...