Great games without a Sequel/Prequel/Spin-Off???

Grim Fandango

Bastion and FTL

Enslaved: Odyssey to the West - they did a real good job in character writing and animation. One of the few games that I was actually sad when it ended. Might only be for consoles though.

Jade Empire & Indigo Prophecy (a.k.a. Fahrenheit).

Far Cry 3

Dishonored

Realm of The Mad God

Deus Ex... well it has sequels but they are completely different stories, you should choose either the original or Human Revolution.

Conker's Bad Fur Day (There's a remake, but that's it). There was a sequel in the works, but FREAKING MS never wanted to give the greenlight.

If PC only that cuts out El Shaddai: Ascension of the Metatron which is a great game not enough people bought (IGN can go DIAF for their review of it. It got the God Hand treatment). For PC I'd say Recettear: An Item Shop's Tale. Aww yeah

Gladius for the orignal Xbox. Considered one of the most underrated games of its time due to terrible marketing, but the game itself was a blast for me. No sequels or prequels at all.

spec ops the line is what you want.

Tales of Legendia

Costume quest, brutal legend, psychonauts(heck i even want a sequel for raz but never announced)

Remember Me - came out in June. There MAY be a sequel/prequel in the works, but nothing has been officially stated and I can tell you that the story does wrap up rather well.

Planescape: Torment. Now there's a story.

Azure Dreams.

metro 2033

pc: Bastion / Lone Survivor / Deadlight ----
x360: lost odyssey / eternal sonata

threads of fate, the world ends with you, i forgot what the third one was i mentioned in chat. -edit, end of eternity.

Enslaved: Odyssey to the West, Breath of Death VII, Shadow Complex(Kinda, there are books and they've been talking about a sequel for awhile)

Bad Rats.

VVVVVV

Fahrenheit. A must play, even though it was released in 2005.