I would go with either League of Legends, Dota or Counter Strike, since every match is different (as long as you play Counter Strike competitively). I love single player games, but you just cannot play them forever (my max was 140 hours in Dragon Age: Origins).
E: also strategy games provide good replayability, any Total War game would also be a good choice. ;)
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Dwarf Fortress. With no other game available i might actually understand it completely.
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Minecraft because it updates every few months and that combined with the mods could keep the game interesting much longer than any other game. RuneScape would be my second choice because it gets 3-4 updates a month so there'd be something new to do almost every week but since it can't be modded I'm not sure if I would want it to be my only game forever.
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RPGWO, it would probably have to be the home server we have though as I think the orignal game is no longer online (I could be wrong on that though). So long as there would never be any server resets (home server would take away the need for these) I could quite happily play this little old game forever.
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The game I want, hasn't been made yet, The game I could see playing forever would be, Arcanum of Steamworks and Magicka Obscura 2, preferably made by Bethesda Softworks, with its combination of magic and technology, and the number of mods that would spring from that perfect union, I could see myself able to play only that game for the rest of my life.
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Depends, can we still mod the game? Or just as is?
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Demon's Souls, I still play that game. Clocking in over 2k hours on it already, help D:
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I'm gonna say Red Dead Redemption. I had completly forgot about it untill I booted up my PS3 again the other day for some serious gaming time.
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